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4 CH1 PHARMACEUTICALS, BIOLOGICS AND BIOPHARMACEUTICALS NH2 H2N N N O S O NH2 Prontosil rubrum (a) NH2 O S O NH2 Sulphanilamide (b) NH PABA Tetrahydrofolic acid (d) NH2 COOH PABA (c) O C NH CH COOH (CH2)2 COOH Glutamic acid OH H N CH2 H N Pteridine derivative H2N N N HH H Figure 1.
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464 Index [T cell] anergy, 228 mechanisms linda raschke forex, 228229 clonal deletion mechanisms, 228 downregulation, 129 cytotoxic T cell late antigen-4, 129 differentiation 152, 129 function in vitro assays, 405406 helper cells, 404 lymphocyte tolerance models, 226229 lidna, 228 clonal deletion mechanisms, 228 regulatory, 229 lymphomas, 394396 receptor, 127 selection, 120 variable region types, 235 subpopulations, flow cytometry and, 404 Tcells, unconventional, 121 T dependent antigens, B lymphocyte response and, 5051 T helper cells, 404 T lineage commitment, 118 T lymphocyte, 9, 4344 activated, 233 differentiation, 142 thymus, role in, 16 distribution, 13 markers, 127 proliferation, 140142 T lymphopoiesis, stages of, 118121 b selection, 119120 cell differentiation, 120121 receptors selection, forx lineage commitment, 118 proliferative expansion, 118 thymic migration, 118 transcription factors, 121 T regulatory cells, 121 T-B lymphocyte cooperation, 3942 T-dependent antigens, 4243 T-independent antigens, 4243 biological basis, 42 response characteristics, 4243 Target cell killing, CD8 effector T cells and, 152 153 Terminal deoxynucleotidyl transferase, 115 Termination of tolerance, 230231 Tetramer assays, 219220 Third complement component, activation and inactivation of, 105 Thrombocytopenia and eczema (Wiskott-Aldrich syndrome), 425 Thymectomy, 436 Thymic migration, 118 Thymus, role in differentiation,16 Thyroid diseases, 243 246 Addisons disease, 246 Graves disease, 243246 Tissue antigen cross reactions, 199 damage, postinfectious, 198 fixed antigen antibody complex detection, 208209 Tolerance, 223230 acquired, 224225 clonal anergy, 224 deletion, 223224 [Tolerance] definition of, 223 induction, 238240 influencing factors, 224 lymphocytes, 225229 mechanisms of, 223 224 mucosal, 229230 self, 5 T lnda, 226 229 termination of, 230231 Toll-like receptors, 185186 Tonsils, 17 Toxin neutralization, 192 Transcription factors B lymphopoiesis and, 126 lymphopoiesis and, 117121 T cell activation and, 140 T lymphopoiesis and, 121 Transfusion effects, 364365 Transient hypogammaglobulinemia of infancy, 418 Transplant rejection, 5 major histocompatibility complex (MHC), 5 Transplantation immunology, 357367 donorrecipient matching, 357359 gaschke rejection, 359361 vs.
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